Shoshanna Zucker

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Shoshanna Zucker, PhD
Assistant Professor
Pharmacy (School of)
DAC 434
zucker@dyc.edu
716-829-7903


Biography

Dr. Shoshanna Zucker joined the Faculty of D’Youville Pharmacy School in 2013.  Prior to this position, she was a Senior Scientist at Roswell Park Cancer Institute.  Her work there focused on gene regulation of oxidative stress and cancer.  She continues to conduct collaborative research at Roswell Park and maintains the title of Faculty Emeritus.  Dr. Zucker also collaborates with a team of Electrical Engineers at the University at Buffalo where she has demonstrated that non-thermal plasma can selectively induce apoptotic cell death in melanoma cells.  Her current research is focused on elucidating the mechanisms of cell death by non-thermal plasma and utilizing genetic and pharmacological methods to enhance this effect.   Dr. Zucker has co-authored numerous publications and grants and was a former recipient of the NIH NRSA fellowship.  Dr. Zucker also has a background in teaching at UB and Roswell Park.  She is currently teaching the Anatomy, Physiology, and Pathophysiology course at D’Youville Pharmacy School.

Education & Training

Iona College (B.S. Biology, magna cum laude)
Albert Einstein College of Medicine (M.S., Molecular Pharmacology)
Albert Einstein College of Medicine (Ph.D., Molecular Pharmacology)

Research Interests

• Gap junctions and cancer
• Oxidative stress and cancer progression
• Non-thermal plasma as a tool to induce apoptotic cell death in melanoma

Publications

Zucker, S.N., Bancroft, T.A., Place, D.E., Des Soye, B., Bagati, A., Berezney, R. (2013) A dominant negative Cx43 mutant differentially affects tumorigenic and invasive properties in human metastatic melanoma cells. J Cell Physiol. 228(4):853-9.

Mannova, S., Moparthy, K.C., Wheeler, L., Natarajan, V., Zucker, S.N., Burhans, W., Zeitouni, N., Matthews, C., Nikiforov, M.A. (2013)  Depletion of Deoxyribonucleotide Pools is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence.  Am J Pathol. 182(1):142-51.

Zucker, S.N., Zirnheld, J., Bagati, A., Disanto, T.M., Des Soye, B., Wawrzyniak, J.A., Etemadi, K., Nikiforov, M., Berezney, R. (2012) Preferential induction of apoptotic cell death in melanoma cells as compared with normal keratinocytes using a non-thermal plasma torch. Cancer Biol Ther. 13(13):1299-306.

Jha A, Gupta S, Zucker S.N., Auerbach A. (2012) The energetic consequences of loop 9 gating motions in acetylcholine receptor-channels.  J Physiol. 590(Pt 1):119-29.

Mannava S, Zhuang, D. Nair, J.R., Bansal, R., Wawrzyniak, J.A., Zucker, S.N., Boise, L.H., Lee, K. and Nikiforov, M.A. (2012) KLF9 is a novel transcriptional regulator of bortezomib- and LBH589- induced apoptosis in multiple myeloma cells.  Blood. 119(6):1450-8.

Zirnheld, J., Zucker, S.N., DiSanto, T.M., Berezney, R. Zirnheld, J. and Etemadi, K. (2010) Non-thermal plasma needle: development and targeting of melanoma cells.  IEEE Transactions on Plasma Science; 38:4.

Zirnheld, J.,  DiSanto, T.M., Burke, K.M.. Zucker, S.N., and Etemadi, K. (2009) Development of an atmospheric pressure non-thermal plasma needle for melanoma cell research.  IEEE Pulsed Power Conference Proceedings; 1429-32

Beahm, D.L., Oshima, A., Gaietta, G.M., Hand, G.M. Smock, A.E. Zucker, S.N., Toloue, M. M. Chandrasekhar, A., Nicholson, B.J., and  Sosinsky, G.E. (2006) Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel. J Biol Chem.;281(12):7994-8009.

Chandrasekhar, A., Merritt, M., Huh, S.J., Nicholson, B.J., and Zucker, S.N. (2004 ) Connexin expression and cell coupling fail to reverse the v-src transformed growth characteristics of a Cx43-/-cell line.  Cell Commun Adhes (2-4):103-19.

Zucker, S.N. & Nicholson, B.J. (2002) Mutagenic approaches to modifying gap junction phenotype. Curr. Drug Targets.  3(1):  441-453.

Erlichman, J., Gutierrez-Juarez, R., Zucker, S., Mei, X., Orr, G.A. (1999) Developmental expression of the protein kinase C substrate/binding protein (clone 72/SSeCKS) in rat testis,  identification as a scaffolding protein containing an A-kinase-anchoring domain which is expressed during late-stage spermatogenesis. Eur. J. Biochem. 263(3):797-805.

Zucker, S.N., Castillo, G., Horwitz, S.B. (1997) Down-regulation of the mdr gene by thyroid hormone during Xenopus laevis development.  Mol. Cell. Endocrin. 129:73-81

Guarini, L., Graham, G.M., Ferrone, S., Zucker, S. and Fisher, P.B. (1992). Modulation of the antigenic phenotype of human melanoma cells by differentiation-inducing and growth-suppressing agents.  Pigment Cell Research 2:123-31.

Guarini, L., Su, Z.Z., Zucker, S., Lin, J., Grunberger, D. and Fisher, P.B. (1992). Growth inhibition and modulation of antigenic phenotype in human melanoma and glioblastoma multiforme cells by caffeic acid phenylethyl ester (CAPE). Cell. Mol. Biol. 38(5):513-27.