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Shoshanna Zucker, PhD

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Assistant Professor

Pharmacy (School of)

DAC 431



Dr. Shoshanna Zucker joined the Faculty of D’Youville Pharmacy School in 2013. Prior to this position, she was a Senior Scientist at Roswell Park Cancer Institute where she studied gene regulation of oxidative stress and cancer. She continues to conduct collaborative research at both Roswell Park and the University at Buffalo where she has demonstrated that non-thermal plasma can selectively induce apoptotic cell death in melanoma cells.

Her current research is focused on elucidating the mechanisms of cell death by non-thermal plasma and utilizing genetic and pharmacological methods to enhance this effect. Dr. Zucker received a Patent in March 2017 on a Novel Combination Therapy for Cancer Research. The focus of Dr. Zucker’s research is testing this therapy with the ultimate goal of Clinical Trials. Dr. Zucker has co-authored numerous publications and grants and was a former recipient of the NIH NRSA fellowship.

Dr. Zucker is currently teaching the Anatomy, Physiology, and Pathophysiology courses at D’Youville Pharmacy School and also participates in teaching the Professional Development of the Student Pharmacist.

Dr. Zucker is a member of the American Association of Cancer Research and the American Association of the Colleges of Pharmacy. Dr. Zucker is the advisor for the Lambda Kappa Sigma Fraternity. Dr. Zucker is a Member of the Dean’s Advisory Board for Iona College. Dr. Zucker is very active in Admissions for DYC and serves as the Research Committee Vice Chair and an advisor for the student led pharmacy research group, SPRA.

Education & Training

Research Interests

Dr. Zucker conducts research at D’Youville College School of Pharmacy with a team including several DYC students and collaborators at both Roswell Park and the University at Buffalo. Dr. Zucker coordinates student presentations at the DYC Research Day and ASPET conferences as well as publications. Dr Zucker’s research is very student focused, comprised of group meetings and student presentations. Senior students participate in training junior students and learn to be effective teachers and pharmacy researchers.

The research that Dr. Zucker focuses on includes:


Polusani, S.R., Kalmykov, E.A., Chandrasekhar, A., Zucker, S.N.*, and Nicholson, B.J.* (2016) Mechanism of Cx26 induced increased migration of HeLa cells. J Cell Science. 129(23); 4399-4410.*These authors share senior authorship of the paper.

Thompson, K., Burke, K., Zirnheld, J. and Zucker, S.N. , Comparison of circuits for the generation of nonthermal plasma for the treatment for melanoma. IEEE Transactions in Plasma Science (in press)

Bagati, A., Koch, Z., Bofinger, D., Goli, H., Weiss, L.S., Dau, R., Thomas, M. and Zucker, S.N. (2015) A modified in vitro invasion assay to determine the potential role of hormones, cytokines and/or growth factors in mediating cancer cell invasion. J Vis Exp. 2015 Apr 24;(98)

Zucker, S.N., Fink, E.E., Bagati, A., Mannava, S., Bianchi-Smiraglia, A., Bogner, P., Foley, C., Grimm, M.J., Moparthy, K., Ionov, Y., Hu, Q., Liu, S., Zhang, Y., Sexton, S., Kaminski, N., Segal, B.H., and Nikiforov, M.A. (2014) NRF2 propagates oxidative stress via induction of KLF9. Mol. Cell 53(6); 916-928

Chandrasekhar, A. Kalmykov, E.A., Polusani, S.R., Mathis, S.A., Zucker, S.N.* and Nicholson, B.J.* ( 2013) Intercellular Redistribution of cAMP Underlies Selective Suppression of HeLa Cell Growth by Connexin26. PLoS ONE. 8(12).* These authors share senior authorship of the paper.

Wawrzyniak JA1, Bianchi-Smiraglia A, Bshara W, Mannava S, Ackroyd J, Bagati A, Omilian AR, Im M, Fedtsova N, Miecznikowski JC, Moparthy KC, Zucker SN, Zhu Q, Kozlova NI, Berman AE, Hoek KS, Gudkov AV, Shewach DS, Morrison CD, and Nikiforov MA. (2013) A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion. Cell Rep. 5(2):493-507

Zucker, S.N., Bancroft, T.A., Place, D.E., Des Soye, B., Bagati, A., and Berezney, R. (2013) A dominant negative Cx43 mutant differentially affects tumorigenic and invasive properties in human metastatic melanoma cells. J Cell Physiol. 228(4):853-9.

Zucker, S.N., Zirnheld, J., Bagati, A., Disanto, T.M., Des Soye, B., Wawrzyniak, J.A., Etemadi, K., Nikiforov, M., Berezney, R. (2012) Preferential induction of apoptotic cell death in melanoma cells as compared with normal keratinocytes using a non-thermal plasma torch. Cancer Biol Ther. 13(13):1299-306.

Mannava S, Zhuang, D. Nair, J.R., Bansal, R., Wawrzyniak, J.A., Zucker, S.N., Boise, L.H., Lee, K. and Nikiforov, M.A. (2012) KLF9 is a novel transcriptional regulator of bortezomib- and LBH589- induced apoptosis in multiple myeloma cells. Blood. 119(6):1450-8.

Zirnheld, J., Zucker, S.N., DiSanto, T.M., Berezney, R. Zirnheld, J. and Etemadi, K. (2010) Non-thermal plasma needle: development and targeting of melanoma cells. IEEE Transactions on Plasma Science; 38:4.

Beahm, D.L., Oshima, A., Gaietta, G.M., Hand, G.M. Smock, A.E. Zucker, S.N., Toloue, M. M. Chandrasekhar, A., Nicholson, B.J., and Sosinsky, G.E. (2006) Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel. J Biol Chem.;281(12):7994-8009.

Chandrasekhar, A., Merritt, M., Huh, S.J., Nicholson, B.J., and Zucker, S.N. (2004 ) Connexin expression and cell coupling fail to reverse the v-src transformed growth characteristics of a Cx43-/-cell line. Cell Commun Adhes (2-4):103-19.

Zucker, S.N. and Nicholson, B.J. (2002) Mutagenic approaches to modifying gap junction phenotype. Curr. Drug Targets. 3(1): 441-453.

Zucker, S.N., Castillo, G., and Horwitz, S.B. (1997) Down-regulation of the mdr gene by thyroid hormone during Xenopus laevis development. Mol. Cell. Endocrin. 129:73-81

Guarini, L., Graham, G.M., Ferrone, S., Zucker, S.and Fisher, P.B. (1992). Modulation of the antigenic phenotype of human melanoma cells by differentiation-inducing and growth-suppressing agents. Pigment Cell Research 2:123-31.

Guarini, L., Su, Z.Z., Zucker, S., Lin, J., Grunberger, D. and Fisher, P.B. (1992). Growth inhibition and modulation of antigenic phenotype in human melanoma and glioblastoma multiforme cells by caffeic acid phenylethyl ester (CAPE). Cell. Mol. Biol. 38(5):513-27.

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