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Joseph Dunn, PhD

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Professor; Associate Dean for Research

Certified Graduate Member, Pharmacy (School of)

DAC 441

dunnj@dyc.edu

716-829-8441

716-829-8436 fax


Biography

Professor Dunn offers an extensive background in the areas of basic and translational chemical and biological sciences.Prior to joining D’Youville as a founding faculty member of the School of Pharmacy, Dr. Dunn held several positions in government and industry including Deputy Undersecretary for the Research, Economics and Education Mission Area of the United States Department of Agriculture, Principal Scientist at Sterling Winthrop Pharmaceuticals Inc., and Senior Research Pharmacologist at the Colgate Palmolive Company. During his over thirty years in research and development, Dr. Dunn initiated and managed numerous projects in areas ranging as broadly as sustainable energy production from agricultural materials to prevention of chronic soft tissue disease in the oral cavity and development of a novel anti-HIV agent.  Besides currently instructing P3 pharmacy students medicinal chemistry and pharmacology in the pharmacotherapeutics sequence courses “Infectious Diseases” (PMD 803) and “Oncology” (PMD 808), Dr. Dunn is also the Associate Dean for Research of the School where he advises both students and fellow faculty in their research endeavors. Finally Dr. Dunn holds numerous positions outside of D’Youville including Director of Brothers of Mercy Nursing and Rehabilitation Center in Clarence NY, Member of the Technology Transfer Committee of the Board of Directors of Roswell Park Cancer Institute in Buffalo, NY and Chief Executive Officer of the National Center of Food and Agricultural Policy in Washington DC.

Education & Training

Research Interests

Dr. Dunn is currently pursuing research in three fields: 

  1.  Identifying potential new anticancer drugs from a proprietary, mid-sized, but multi-structurally focused chemical library.
  2. Understanding the mechanisms of action of novel salicylanilides as both potential anticancer agents and antimicrobial agents.
  3. Optimizing formulations of calcium sulfate for use as bone regeneration materials.  

For Project 1, we are performing high throughput screening to identify potential activators of autophagy and apoptosis in human tumor cells utilizing robotics and fluorescent/luminescent readouts (in collaboration with OmniPharm Research International Inc. and its industrial partners).

For Project 2 we are correlating IC50 values for cell growth inhibition to target activity inhibition such as EGFrTK inhibition in human cancer cells and histidine kinase inhibition in bacterial cells.  For Project 3 we are assisting in the assessment of different hydrated forms of calcium sulfate in attempts to identify bone grafting materials with the greatest potential to support optimal bone regrowth into critical defects first in the oral cavity and then in other bone where grafts are required (in collaboration with ProOsseous LLC and its industrial partners).  The research laboratories at D’Youville College School of Pharmacy are fully equipped to perform routine and some specialized pharmaceutical experiments such as though required for solid and liquid dosage form preparations, chemical synthesis, chemical analysis (including HPLC/MS) and drug candidate screening using bacteria, cultured cells and zebra fish.

Publications/Presentations

Dunn, JA and Blumberg, PM (1983), Specific Binding of [20-3H]12 deoxyphorbol 13-isobutyrate to phorbol ester receptor subclasses in mouse skin particulate preparations. Cancer Res 43, 4632-4637.

Blumberg, PM, Dunn, JA, Jaken, S, Jeng, AY, Leach, KL, Sharkey, NA and Yeh, E (1984), Specific receptors for phorbol ester tumor promoters and their involvement in biological responses. In, Slaga, T (ed), Mechanisms of Tumor Promotion 3. Tumor Promotion and Co-carcinogenesis in-vitro, CRC press, Boca Raton, Fl, 143-184.


Dunn, JA, Jeng, AY, Yuspa, SH and Blumberg, PM (1985), Heterogeneity of [3H]-phorbol 12,13-dibutyrate in primary mouse keratinocytes at different stages of maturation. Cancer Res 45, 5540-5546.


Dunn, JA, Faletto, MB, Kasper, SJ and Gurtoo, HL (1992), Aflatoxin transformed C3H10T1/2 cells overexpress protein kinase C and have an altered response to phorbol esters treatments, Cancer Res, 52, 990-996.


Dolle, RE, Dunn, JA, Bobko, M, Singh, B,  Kuster, JE, Baizman, E, Harris, A, Sawutz, DG, Miller, D, Wang, S, Faltynek, CR, Xie, W, Sarup, J, Bode, DC, Pagani, ED, and Silver, PJ (1994), 5,7-Dimethyl-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular ß-type platelet-derived growth factor receptor tyrosine kinase.  J Med Chem 37, 2627-2629.


Sawutz, DG., Bode, DC, Briggs, GM, Reid, JR, Caniff, P, Caldwell, L, Faltynek, CR, Miller, D, Dunn, JA, de Garavilla, L, Guiles, JW, Weigelt, C, Michne, W, Treasurywala, AM and Silver, PJ (1996), In Vitro  characterization of a novel series of platelet-derived growth factor receptor tyrosine kinase inhibitors. Biochem Pharm. 51, 1631-1638.


Chadha, KA, Dembinski, WE, Dunn, CB, Aradi, J., Bardos, TJ, Dunn, JA, and Ambrus, JA (2004) Effect of increasing thiolation of the polycytidylic acid strand of poly I:poly C on the alpha, beta and gamma interferon-inducing properties, antiviral and antiproliferative activities..  Antiviral Res. 64(3):171-7.


Horvath, A.,  Tokes, S.,  Hartman, T., Watson, K, Turpin, J.A., Buckheit, Jr., R.W.,  Sebestyen, A., Szollosi, J., Benko, I., Bardos,  T.J., Dunn, JA,  Fesus, L., Ferenc, Toth, D. and Aradi, J.  (2005) Potent inhibition of HIV-1 entry by (s4dU)35. Virology 334: 214-223.


Horváth A, Beck Z, Bardos TJ, Dunn JA, Aradi J. (2006) Effect of the extent of thiolation and introduction of phosphorothioate internucleotide linkages on the anti-HIV activity of Suligovir [(s4dU)35]. Bioorg Med Chem Lett. 16(20):5321-3. Epub 2006 Aug 22


Buchanan, GA, Dunn, JA, Fischer, JR, Johnson, SR, Finnell, JA and Lavoie, BD, (February, 2008).  The New Paradigm in Agriculture,  In Resource - Engineering & Technology for a Sustainable World, published by ASABE- American Society of Agricultural and Biological Engineers, 16-18.


Buchanan, GA, Dunn, JA, Fischer, JR, Johnson, SR, Finnell, JA and Lavoie, BD, (April, 2008).  Biomass Feedstocks: Opportunities to Increase Biofuels.  In Resource - Engineering & Technology for a Sustainable World, published by ASABE- American Society of Agricultural and Biological Engineers, 7-8.


Buchanan, GA, Dunn, JA, Fischer, JR, Johnson, SR, Finnell, JA and Lavoie, BD, (July, 2008)  From Field to Biorefinery: Biomass Harvesting, Handling, Transport, and StorageIn Resource - Engineering & Technology for a Sustainable World,  published by ASABE- American Society of Agricultural and Biological Engineers, 5-7.


Buchanan, GA, Dunn, JA, Fischer, JR, Johnson, SR, Finnell, JA and Lavoie, BD, (September, 2008). Biobased Products. In Resource - Engineering & Technology for a Sustainable World, published by ASABE- American Society of Agricultural and Biological Engineers, 10-15.


Buchanan, GA, Dunn, JA, Fischer, JR, Johnson, SR, Finnell, JA and Lavoie, BD, (November, 2008). Converting Biomass into Fuels - Expanding Commercial Applications and Developing New Technologies. In Resource - Engineering & Technology for a Sustainable World, published by ASABE- American Society of Agricultural and Biological Engineers.

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